Scientific Impact

Today, LOCUS MEDICUS employs 10 scientists of Postdoctoral and PhD level and 4 Postgraduate (MSc) level scientists. At the same time, it fully funds their continuous education and provides new specializations through international conferences, workshops and training. Furthermore, on a weekly basis, postgraduate level presentations are organized in the premises of the clinic by its own scientific staff or by invited lecturers.

As a research facility, it has produced more than 20 international peer reviewed publications in scientific journals and has participated in more than 60 national and international scientific conferences. LOCUS MEDICUS publications can be found below.

LOCUS MEDICUS, has also fully or partially funded and accommodated on its premises the experimental work of 7 PhD and 2 MSc diplomas and many undergraduate student placements, from Greek and UK universities.

 

International Publications of Locus Medicus

 

Molecular investigation of menstrual tissue for the presence of C. Trachomatis, M. Hominis and U.Urealyticum collected by women with a history of infertility.

Michou I. V, Constantoulakis P., Makarounis K., Georgoulias G.,  Kapetanios V., Tsilivakos V.  The Journal of Obstetrics and Gynaecology Research. 2013 (early on-line version doi:10.1111/jog.12165).

  1. Department of Molecular Pathology and Genetics, Locus Medicus Laboratory, Athens, Greece. 
  2. Department of Infertility, Locus Medicus Laboratory, Athens, Greece. 
  3. Embryology and Histology Department, Medical School, National and Kapodistrian University of Athens, Athens, Greece

Successful bone marrow transplantation in a pediatric patient with chronic myeloid leukemia from a HLA-identical sibling selected by preimplantation HLA testing.

Goussetis E., Constantoulakis P., Kitra V., Peristeri I., Baka M., Papadimitropoulos M., Karamolegos C., Paisiou A., Vasilatou-Kosmidis H., Graphakos S., Pediatr. Blood Cancer. 2011 Aug;57(2):345-7. doi: 10.1002/pbc.23007. Epub 2011 Mar 24..  2011.

  1. Locus Medicus S.A., Athens, Greece.
  2. Stem Cell Transplant Unit, Aghia Sophia Children's Hospital, Athens, Greece.
  3. Embryogenesis S.A., Athens, Greece.

MIRU-VNTR typing of drug-resistant tuberculosis isolates in Greece.

Nikoletta Rovina, Simona Karabela, Pantelis Constantoulakis, Vassiliki Michou, Konstantinos Konstantinou, Vassileios Sgountzos, Charis Roussos and Nikolaos Poulakis. Adv Respir Dis, 7 April 2011.

  1. Locus Medicus Laboratory, Athens, Greece.
  2. 1st University Pulmonary Department, Medical School, National and Kapodistrian University of Athens 'SOTIRIA' District Chest Diseases Hospital, 152 Mesogion Street, 11527 Athens, Greece.

Ιn vivo expression of innate immunity markers in patients with mycobacterium tuberculosis infection.
  1. Pantelis Constantoulakis, Eftihia Filiou, Nikoletta Rovina, George Chras, Aggeliki Hamhougia, Simona Karabela, Adamandia Sotiriou, Charis Roussos, Nikolaos Poulakis. BMC Inf. Dis. 2010, 10:243.
  2. Locus Medicus, Molecular Pathology and Genetics Dept., Athens, Greece.

Αcute apenditis in patient with acute promyelocytic leukemia.

Papageorgiou SG, Foukas P, Economopoulou C, Tsirigotis P, Sakorafas G, Georgakopoulos N, Kefala M, Pappa V, Economopoulos T, Panayiotides I, Papageorgiou E, Dervenoulas (2011) J. Leuk Res. Jan;35(1):e4-5. Epub 2010 Sep 19

  1. Locus Medicus Laboratory, Athens, Greece.
  2. Second Department of Internal Medicine, Propaedeutic, Haematology Unit, University General Hospital "Attikon", Haidari, Greece. 

Are Educators at High Risk of Sub-fertility? A Multicenter Study.

Perros G., Tzonis P., Tsilivakos V., Gerofotis A., Dalavitsou V., Vassilaki A., Keramitsoglou T., Papaioannou D., Moschandreou D., Kontopoulou-Antonopoulou V., Daniilidis M., Varla-Leftherioti M. (2011) Am J Reprod Immunol.Apr;65(4):415-20. Epub 2010 Aug 16.

  1. Locus Medicus Laboratory, Athens, Greece.
  2. Immunobiology Dept "Helena Venizelou" Maternity Hospital, Athens, Greece.

Herpes Virus Infected Spermatozoa Following Density Gradient Centrifugation for IVF Purposes.

Michou V., Liarmakopoulou S., Thomas D., Tsimaratou K.,  Makarounis K.,  Constantoulakis P., Angelopoulou R., Tsilivakos V. (2011). Andrologia (early on-line version).

  1. Locus Medicus Laboratory, Athens, Greece.
  2. Diagnosi-IVF, Athens, Greece.
  3. National and Kapodistrian University of Athens,  Pathophysiology  Clinic, Endocrine Unit, Athens, Greece.
  4. National and Kapodistrian University of Athens,  Embryology and Histology Department, Athens, Greece. 

In Vivo Expression of Innate Immunity Markers in Patients with Mycobacterium Tuberculosis Infection.

Constantoulakis P., Filiou E., Rovina N., Chras G., Hamhougia A., Karabela S., Sotiriou A., Roussos C., Poulakis N. (2010). BMC Infect Dis., 10, 243.

  1. Locus Medicus, Molecular Pathology and Genetics Dept., Athens, Greece.

Myocardial Inflammation in Duchenne Muscular Dystrophy as a Precipitating Factor for Heart Failure: a Prospective Study.

Mavrogeni S., Papavasiliou A., Spargias K., Constandoulakis P., Papadopoulos G., Karanasios E., Georgakopoulos D., Kolovou G., Demerouti E., Polymeros S., Kaklamanis L., Magoutas A., Papadopoulou E., Markussis V., Cokkinos DV. (2010). BMC Neurol.,10, 33.

  1. Locus Medicus Laboratory, Athens, Greece.
  2. Cardiology Department, Onassis Cardiac Surgery Center, Athens, Greece. 

Wound Healing After Laser Skin Resurfacing: The Effect of a Silver Sulfadiazine-Hyaluronic Acid-Containing Cream Under an Occlusive Dressing.

Kontoes P.P., Vrettou C.P., Loupatatzi A.N., Marayiannis K.V., Foukas P.G., Vlachos S.P. (2010). J Cosmet Laser Ther. 12(1), 10-3.

  1. Locus Medicus Laboratory, Athens, Greece.
  2. Laserlight Clinic, Athens, Greece.

Sequence-Based Genotyping HPV L1 DNA and RNA Transcripts in Clinical Specimens.

Satra M., Vamvakopoulou D.N., Sioutopoulou D.O., Kollia P., Kiritsaka A., Sotiriou S., Antonakopoulos G., Alexandris E., Costantoulakis P., Vamvakopoulos N.C. (2009) Pathol Res Pract., 205(12):863-9.

  1. Locus Medicus Laboratory, Athens, Greece.
  2. Department of Biology and Genetics, University of Thessalia Medical School,  Larisa, Greece. 

Myocardial Inflammation in Autoimmune Diseases: Investigation by Cardiovascular Magnetic Resonance and Endomyocardial Biopsy.

Mavrogeni S., Spargias K., Markussis V., Kolovou G., Demerouti E., Papadopoulou E., Stavridis G., Kaklamanis L., Douskou M., Constantoulakis P., Cokkinos DV. (2009). Inflamm Allergy Drug Targets., 5, 390-7.

  1. Locus Medicus Laboratory, Athens, Greece.
  2. Onassis Cardiac Surgery Center, Athens, Greece.

Endomyocardial HSV-II Detection in an Infant with Dilated Cardiomyopathy.

Mantadakis E., Thomaidis S., Thomaidis A., Constantoulakis P., Rammos S., Chatzimichael A. (2009) J. Clin. Virol. (in Press).

  1. Locus Medicus Laboratory, Athens, Greece.

Detection of Herpes Virus DNA in Post-Operative Thyroid Tissue Specimens of Patients with Autoimmune Thyroid Disease.

Thomas D, Liakos V, Michou V, Kapranos N, Kaltsas G, Tsilivakos V, Tsatsoulis A. (2008). Exp Clin Endocrinol Diabetes. 116(1), 35-9. 

  1. Locus Medicus Laboratory, Athens, Greece.
  2. Department of Endocrinology, Diabetes and Metabolism, Metaxa Memorial Anticancer Research Hospital, Piraeus, Greece. 

Fatal Disseminated Bocavirus Infection in a Young Transplant Patient.

Kyriazi V., Manaka A., Balotis C-G., Konstandoulakis P., Baltadakis I., Karakasis D.,  Apostolidis I., Harhalakis N., Nikiforakis E. (2008) Int J Infectious Disease., 12, S18-S18.

  1. Locus Medicus Laboratory, Athens, Greece.
  2. BMT Unit, Evaggelismos Hospital, Athens, Greece.

Evidence for Association of the G1733A Polymorphism of the Androgen Gene with Recurrent Spontaneous Abortions.

Karvela M., Stefanakis N., Papadopoulou S., Tsitilou S.G., Tsilivakos V., Lamnissou K. (2008). Fertil Steril., 90(5):2010.e9-2010.e12.

  1. Locus Medicus Laboratory, Athens, Greece.
  2. Department of Biology, Division of Genetics and Biotechnology, University of Athens, Athens, Greece.

Expression of Oncofetal RNA-Binding Protein CRD-BP/IMP1 Predicts Clinical Outcome in Colon Cancer.

Dimitriadis E., Trangas T., Milatos S., Foukas P.G., Gioulbasanis I., Courtis N., Nielsen F.C., Pandis N., Dafni U., Bardi G., Ioannidis P. (2007). Int J Cancer., 1;121(3), 486-94.

  1. Locus Medicus Laboratory, Athens, Greece.
  2. Department of Genetics, Saint Savvas Oncological Hospital, Athens, Greece.

Altered Immunophenotypic Parameters in Infertile Women. Possible Role of Herpes Viremia.

Thomas D., Michou V., Moustakarias T., Aleporou V., Matzavinos T., Mitsakos-Barbagiannis K., Kalofoutis A., Tsilivakos V. (2005). Am J Reprod Immunol. 54(2), 101-11.

  1. Locus Medicus Laboratory, Department of subfertility, Athens, Greece. 

The Effect of Valacyclovir Treatment on Natural Killer Cells of Infertile Women.

Thomas D., Michou V., Tegos V., Patargias T., Moustakarias T., Kanakas N., Mantzavinos T., Apostolidis C., Salamalekis E., Kalofoutis A., Tsilivakos V. (2004). Am J Reprod Immunol., 51(3), 248-255.

  1. Department of subfertility, Locus Medicus Laboratory, Athens, Greece.

Alterations in the Proliferating Compartment of Gastric Mucosa During Helicobacter Pylori Infection: The Putative Role of Epithelial Cells Expressing p27(kip1).

Sougioultzis S., Foukas P.G., Tzivras M., Kourtessas D., Gorgoulis V.G., Davaris P., Archimandritis A.J. (2003). Mod Pathol., 16(11), 1076–1085.

  1. Locus Medicus Laboratory, Athens, Greece.
  2. Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

Detection of Human Telomerase Reverse Transcriptase mRNA in Urine of Patients with Bladder Cancer: Evaluation of an Emerging Tumor Marker.

Melissourgos N., Kastrinakis N.G., Davilas I., Foukas P., Farmakis A., Lykourinas M. (2003). Urology., 62(2), 362-367. 

  1. Locus Medicus Laboratory, Athens, Greece.
  2. Department of Urology, G. Gennimatas General Hospital, Athens, Greece.

The Fraction of Peripheral Blood CD56 + /CD16 - /CD3 - Subpopulation on Total Natural Killer Cells as an Indication of Fertility-Infertility.

Michou V.I., Kanavaros P., Athanassiou V., Chronis G.B., Stabamas S., Tsilivakos V. (2003). Fertil Steril., 80 Suppl 2:691-7

  1. Locus Medicus Laboratory, Athens, Greece.
  2. Genetics and Biotechnology Department, Faculty of Biology, University of Athens, Ilissia, Greece. 

Expression of HLA-DR is Reduced in Tumor Infiltrating Immune Cells (TIICs) and Regional Lymph Nodes of Non-Small-Cell Lung Carcinomas. A Putative Mechanism of Tumor-Induced Immunosuppression?

Foukas P.G., Tsilivakos V., Zacharatos P., Mariatos G., Moschos S., Syrianou A., Asimacopoulos P.J., Bramis J., Fotiadis C., Kittas C., Gorgoulis V.G. (2001). Anticancer Res. 21(4A), 2609-15.

  1. Locus Medicus Laboratory, Athens, Greece.
  2. Department of Histology and Embryology, Medical School, University of Athens, Greece.

 

 

International Conferences

 

Molecular fingerprinting of mycobacterium tuberculosis isolates in new cases of tuberculosis using Mycobacterial Interspersed Repetitive Unit–Variable Number Tandem Repeat Genotyping (MIRU-VNTR) - Epidemiology of drug resistant tuberculosis in Greece.
  1. N. Rovina, S. Karabella, P. Constantoulakis, V. Michou, K. Konstantinou, V. Sgountzos, Ch. Roussos, N. Poulakis
  2. Unit of Respiratory Infectious Diseases, 1st University Respiratory Clinic, Sotiria Hospital, Athens, Greece
  3. National Center of Tuberculosis, Microbiology Dpt, Sotiria Hospital, Athens, Greece
  4. “Locus Medicus” Research Center, Athens, Greece
  5. Clinic of Multi-drug Resistant Tuberculosis, Sotiria Hospital, Athens, Greece 
International conference of American thoracic society, 14-19 May, 2010 New Orleans, USA.

In vivo expression of innate immunity markers in patients with mycobacterium tuberculosis infection.

Pantelis Constantoulakis, Eftihia Filiou, George Chras, Aggeliki Hamhougia, Simona Karabela, Nikolleta Rovina, Adamandia Sotiriou, Charalambos Roussos, Nikos Poulakis

5th Congress of the International Union Against Tuberculosis and Lung Disease, 27 - 30 May 2009, Dubrovnik – Croatia.

Cardiovascular magnetic resonance assessment of myocarditis and comparison to histology and real time polymerase chain reaction: the emerging role of chlamydia

Sophie Mavrogeni, Menelaos Manousakis, Konstantinos Spargias, Pantelis Konstantoulakis, Genovefa Kolovou, Eftihia Demerouti, Evangelia Papadopoulou, Marouso Douskou, Haralambos Moutsopoulos and Dennis V Cokkinos

11th Annual SCMR Scientific Sessions, Los Angeles, CA, USA. 1–3 February 2008.

Fatal disseminated bocavirus infection in a young transplant patient

Vicky Kyriazi, 1Aikaterini Manaka, 1Constantine-George Balotis, 2Pantelis Konstandoulakis, 1Ioannis Baltadakis, 1Dimitri Karakasis, 1Ioannis Apostolidis, 1Nicholas Harhalakis, 1Emannuel Nikiforakis.

  1. BMT Unit, Evaggelismos Hospital
  2. Locus Medicus Laboratory, Athens, Greece 
15th International Symposium on Infections in the Immunocompromised Host, June 22-25 2008, Thessaloniki, Greece.

Fatal Disseminated Bocavirus Infection in a Young Transplant Patient

Vicky Kyriazi, Aikaterini Manaka, Constantine-George Balotis, Pantelis Konstandoulakis, loannis Baltadakis, Dimitri Karakasis, loannis Apostolidis, Nicholas Harhalakis, Emannuel Nikiforakis

International Journal of Infectious Diseases, Volume 12, Supplement 2, June 2008, Page S18

Herpes virus presence following density gradient semen washing technique.

Liarmakopoulou S, Michou V, Thomas D, Pappa H, Argyriou T, Apostolidis C, Xidias G, Tsilivakos V. 

13th World Congress on In Vitro Fertilization Assisted Reproduction and Genetics: Istanbul, Turkey, May 26-29, 2005. 

HSV infected spermatozoa following ART washing procedure.

Michou V, Liarmakopoulou S, Thomas D, Pappa H, Argyriou T, Apostolidis C, Xidias G, Tsilivakos V. 

European Society Of Human Reproduction and Embryology, 21st Annual Meeting, Copenhagen, 19-22 June, 2005. 

Rapid and accurate detection of Beta-Globin Gene (HBB) mutations by Denaturing High Performance Liquid Chromatography (DHPLC).

Bournazos S, Tserka A

12th International Clinical genetics Seminar on PRENATAL DIAGNOSIS, Athens, 2004.

Acyclovir treatment of herpes virus infected spermatozoa and possible effect on IVF outcome.

D. Thomas, V. Michou, N. Kapranos, T. Moustakarias, A. Kalofoutis, V. Tsilivakos. 

18th Congress of European Society for Urological Research, 4-6 November, Athens, 2004.

The effect of valacyclovir treatment on NK cells of women with a history of infertility.

Thomas D, Michou V, Sakarellos A, Apostolidis A, Pistofidis G, Tegos V, Moustakarias T, Kanakas N, Matzavinos T, Tsilivakos V. 

4th Congress of the European society for Reproductive and Developmental Immunology. Rhodes, June 2003 

The fraction of peripheral blood CD56+/CD16+/CD3- on total natural killer cells as an indication of fertility-infertility.

Michou V, Tsilivakos V, Athanassiou V, Chronis G, Patargias T. 

The 4th congress of The European Society for Reproductive and Developmental Immunology, Rhodes, 2003.

Differences of clinical findings in aborters experiencing effortless and difficult conception.

Michou V, Chronis G, Zafiridis G, Athanassiou V, Kopsidas E, Mitsakos E, Tegos V, Tsilivakos V. 

The 4th congress of The European Society for Reproductive and Developmental Immunology, Rhodes, 2003.